Dr JinHeng Lin

I am an early-career researcher at the Department of Pharmacology, investigating the ion channels and cellular pathways regulating vascular function in small arteries. My current project, funded by the British Heart Foundation, focuses on the effects of neuropeptide Y on coronary microvascular function. Our most recent publication identified a mechanistic link between the Gβγ subunit and small artery vasoconstriction to NPY.

At Worcester I am a tutor for first year Medicine, specialising in vascular physiology, pharmacology, and cellular signalling pathways of muscle contraction. Additionally, I lecture and offer tutorials for the third year FHS Cardiovascular Science option. I also lead and demonstrate for smooth muscle pharmacology practicals, and supervise FHS and MSc project students.

• Lin, J., Scullion, L., Garland, C. and Dora, K., 2023. Gβγ subunit signalling underlies neuropeptide‐Y‐stimulated vasoconstriction in rat mesenteric and coronary arteries. British Journal of Pharmacology.
• Wallis, L., Donovan, L., Johnston, A., Phillips, L.C., Lin, J., Garland, C.J. and Dora, K.A., 2023. Tracking endothelium-dependent NO release in pressurized arteries. Frontiers in Physiology, 14, p.1108943.
• Lin, J., Gettings, S.M., Talbi, K., Schreiber, R., Taggart, M.J., Preller, M., Kunzelmann, K., Althaus, M. and Gray, M.A., 2023. Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channels. Pflügers Archiv-European Journal of Physiology, 475(2), pp.167-179.
• Dora, K.A., Lin, J., Borysova, L., Beleznai, T., Taggart, M., Ascione, R. and Garland, C., 2022. Signalling and structures underpinning conducted vasodilation in human and porcine intramyocardial coronary arteries. Frontiers in Cardiovascular Medicine, p.2243.
• Saint-Criq, V., Wang, Y., Delpiano, L., Lin, J., Sheppard, D.N. and Gray, M.A., 2021. Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors. Journal of Cystic Fibrosis, 20(5), pp.843-850.
• Lin, J., Taggart, M., Borthwick, L., Fisher, A., Brodlie, M., Sassano, M.F., Tarran, R. and Gray, M.A., 2021. Acute cigarette smoke or extract exposure rapidly activates TRPA1-mediated calcium influx in primary human airway smooth muscle cells. Scientific Reports, 11(1), pp.1-15.
• Saint-Criq, V., Delpiano, L., Casement, J., Onuora, J.C., Lin, J. and Gray, M.A., 2020. Choice of differentiation media significantly impacts cell lineage and response to CFTR modulators in fully differentiated primary cultures of Cystic Fibrosis human airway epithelial cells. Cells, 9(9), p.2137.